E4 Comfort

About the Study

The E4Comfort Study is evaluating an oral study medication to see if it may reduce hot flashes and night sweats in post-menopausal women. Estetrol, the study medication, is a synthetic form of the naturally occurring estrogen. 

How Can I Qualify?

You may be able to participate if you:

  • Are a post-menopausal woman aged 40-65 years
  • Experience moderate-to-severe hot flashes or night sweats
  • Do not have a history of cancer, diabetes, or heart disease

Additional requirements will apply. The study staff can provide more details.

Participation in this study is completely voluntary, and you may withdraw from the study at any time.

Why Participate?

  • All study-related care will be provided at no cost

  • The study staff will closely monitor you and your symptoms

  • You will be helping to advance knowledge of women’s health

See If You Pre-Qualify

The information you provide will be kept confidential.

About Hot Flashes and Night Sweats

Hot flashes and night sweats can be uncomfortable and disruptive. They are, however, a real medical condition that can be treated. If you have moderate-to-severe hot flashes, consider participating in a clinical research study.

What happens during a hot flash?

A hot flash is a sudden sensation of heat in the face, neck, chest, or all over that may cause you to become flushed and sweat heavily. Hot flashes that happen at night are called night sweats.

Up to 80% of women experience hot flashes during menopause.*

Hot flashes may be caused by fewer hormones, such as estrogen and progesterone, being produced during menopause. These changes in hormone levels can affect your body’s temperature-control system.

*Avis, et al., JAMA Intern Med. 2015;175(4):531-539. doi:10.1001/jamainternmed.2014.8063


See If You Pre-Qualify

The information you provide will be kept confidential.

Frequently Asked Questions

About Clinical Research Studies

About the E4Comfort Study

Study Medication

Privacy, Stopping Participation, Costs and Permission